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March 5th 2007. beginning of the day at the polyclinic

platelet.gif

platelet , noun | Physiology : a small colourless disc-shaped cell fragment without a nucleus, found in large numbers in blood and involved in clotting. (Oxford Dictionary)

Because of a nasty genetic disease affecting her blood, my sister produces too many platelets and the platelets cause her blood to thicken too much, this in the long run obviously leads to thrombosis, thus higher chance of stroke, ischemia, arteriosclerosis etcetera. She is 35 and they say the worse is not supposed to happen anytime soon, especially if she responds well to the containment drugs. Although right now her body doesn't seem to tolerate very well the mini aspirin, which is the standard treatment in these cases.

I went at the polyclinic today to make a HLA typing test in the not desirable case my sister should go for a bone marrow transplant in the next future. HLA stays for Human Leukocitye Antigenes, aka the major indicator of genetic compatibility between individuals.
My sister is being cured in Rome, and since the HLA test is very expensive the hospital here in Milan had to wait for some papers from Rome to arrive to authorize the test, and although it's not urgent, getting to the hospital I feel better that the papers arrived before I left for the U.S.

Later I am in the room where they take your blood for analysis. The doctor attends my arm phial after phial outlining for me the purpose and utility of the HLA typing test. She says that in case of bone marrow transplant the test must give 90% of compatibility, which is pretty hard to get. "There's only so little probability for siblings to be that compatible, actually only 25% chance to get there, and almost zero chance for any two random individuals", she says.
And the thing is risky too, I mumble.
"It is risky for the recipient", she says, "whose blood cells have to be 'destroyed' before the operation".
She makes a quick gesture outward with her hands turned down, flickering her fingers to picture the event of destruction. She doesn't go into the details of such a destruction, or the risks involved with it. She's so adapted to underplay the little annoyances of being a donor to persuade people to donate that she seems to be forgetting for a second there that she's talking about my sister's blood cells to possibly be "destroyed".
But I am afraid to ask more. She has sweet oblique eyes, dark hair and large cheek bones like certain italians have, a motherly suffering air about her that makes her immediately sympathetic. She doesn't want me to think at the details now, it's too early, and she's right I guess.
There is also a risk for the donor, right? I say then, feeling a bit coward and provocateur as I say it, and she replies, quick: absolutely not, no! Persuasive.
Behind us another doctor is going about the papers, curly blond hair and a larger body, also very gentle wider eyes. I feel weird and self-conscious as I sit there saying the names of my parents out loud for the family tree form she's filling in. I wonder for a second when it was the last time I pronounced those names.
Finally they hand me all the leaflets about being a donor, and about the bone marrow transplant, give me my documents back and off I go, rolling down the sleeve.

Strangely enough, be it for logistical considerations, or possibly for reasons of persuasion, to get in and out of the room where they take your blood for analysis one has to pass across the hall where the regular blood donors lay down and give blood. So as I walk by, at least a dozen are laying down calmly looking up at the ceiling or sideways eying the doctors, nurses, patients and special occasional potential donors like me passing by for the analysis. A very pretty girl, all dressed in black, is laying down on one of the stretchers listening to her earpieces. For a second there I have the disturbing feeling she's not even donating, she's just laying there listening to music.

Outside is still another warm day. I go across the area of the polyclinic to via commenda to finally get me something to eat. A little later I am sitting in a bar eating focaccia and reading the leaflets about bone marrow transplant.
To my disappointment nowhere on the leaflet (which is not a leaflet at all, actually, but just some xeroed pages stapled together) is said anything about the risks for the recipient. The possibility of rejection is mentioned where it explains the HLA compatibility numbers, and that's it. Nothing is said of the "destruction" of the cells the lady was referring to.
There are few laconic lines about the risks that the donor runs, though. A "very little but not null" chance of a "breaking of the spleen" is mentioned,"possibility of cerebrum-vascular accidents" and "myocardial ischemia", following the "mobilization" and alteration of the blood that the donor must undergo in order to produce more stem cells before the transplant. Wow, just great.

Out of the bar. Is the sky turning gray? Is it a sunny day? Fuck who knows. It's warm. I walk down the street wondering all the things it is stupid to wonder, like what if we she really will need the transplant? And what if we are not compatible?
Me and my sister never got along very much. Nobody really got along with anybody in our so called family. We never mentioned or proved our reciprocal feelings for each other in any way during the years and so, one wonders if the feelings are really there. Well, I wonder all the time and I never got a clear answer.
And if I ever have to do something so important for my sister... at least I want to do it right, to come out right. To be useful.

I curse science and doctors. I curse medicine. I walk by the Berchet high school, the second hour bell just ringing, a girl's running in, the heavy knapsack slamming her back back. Maybe her second hour is science.
Fuck, science. There are the moments of truth when one sees clearly. I have one right there at the end of via commenda. I sort of always knew that science existed to overcome fear, and suddenly I see it so clearly. The reasons, the hope, the results, the hopeless too. So mixed up.


 
 

 

4 Responses to “beginning of the day at the polyclinic” :

Gazing... said

Heh, so true. Kind of like religion, but with a few snippets of data to toss around…

elsa said

I am a bone marrow donor… or at least I am on the list and wish to me. I am a regular blood donor as well but have said for years that nothing would be more satisfying to me than to have the privilege to save someone’s kid, or husband… or sister.

I do have a friend - her father was actually called off the registry and donated… said it was one of the best experiences of his life and I am sure I would feel the same way. It is almost a dream I am able to do this before I die. :-)

J.Doe said

Good luck to your sister. I once donated blood plasma for a girl with leukemia who on the outside had nothing in common with me but on the inside she did.

corpodibacco said

gazing… don’t get me wrong, I tend to love science. That was just a feeling of the moment like there’s many, due to the uncertainty and the probability. Nothing very rational with it. I am grateful to be living this age. Most of the times science does make us freer, and as you say, what’s wrong with it is probably exactly the unconscious attitude of mistaking it for a religion and imagining it has more power that it actually does. One has just to come to terms with it.

elsa: it’s great that you feel so positive about the whole thing. me, I don’t live things that way… and in this special case I don’t think it could ever turn out to be one of the best experiences of my life, not only because of the risks for my sister, and because having to do it would mean that my sister isn’t doing well, but because I generally don’t enjoy hospitals and all that. Also I don’t usually get a kick out of being good or doing good — maybe only if it would really be useful and good for everyone. But how could I be sure of that now? (yeah, being a little more positive would help me, I admit it :))

j.doe: thanks a lot. I am wondering exactly how much in common me and my sister have, actually. We are not lookalikes, we have different natures, habits, on possibly every front. It would be amazing to discover we are very similar genetically, although still nobody knows what exactly that means in the end.

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